Knox was sentenced in January to 28 years and six months in prison for the crime - which took place at the home she shared with Kercher in Perugia in 2007 - while her Italian ex-boyfriend Raffaele Sollecito received a 25-year jail sentence.
Releasing their reasoning behind the conviction earlier this week, judges said that the pair had killed the British student after a fight broke out between her and Knox.
Judges said that Rudy Guede, who is currently serving a 16-year jail sentence for the murder, “behaved impolitely” towards Kercher, who interrupted an “intimate moment” between Knox and Sollecito to complain.
"The cohabitation had reached such a level of exasperation" that the argument quickly escalated, with Guede, Knox and Sollecito "collaborating to immobilize Meredith and use violence against her," the explanation said.
But Knox on Thursday refuted the judge’s reasoning, arguing that she was developing a friendship with her housemate.
“I did not kill my friend...in the month that we were living together, we were becoming friends,” she told American TV channel CNN. “We had never fought,” Knox said.
During the trial prosecutors said that Kercher had a particularly fraught relationship with Knox, who regularly brought men back to their home for sex and left vibrators lying around.
But Knox this week said that while “maybe Meredith was a little bit uncomfortable about certain issues of hygiene...these were not issues that were going to ever lead to any kind of violence.”
“They never led to any kind of aggressive communication between us,” Knox said.
Judges, however, argued that DNA evidence links her and the two men to the scene, with Knox wielding the knife which killed Kercher.
Watch the video interview: