Extending a long-standing relationship with the Italian fashion house, the American singer was snapped for the new campaign by photographers Mert Alas and Marcus Piggott, who captured her in black and white, standing showing off her lean frame and sitting poised on the edge of a chair.
"Madonna is one of the true icons of Versace," designer Donatella Versace said in a statement.
"I am thrilled to have my friend and the most powerful and directional artist as the face of Versace for Spring 2015," she said.
Decked out in a laser-cut leather dress, Madonna shoots the viewer a smouldering look framed by the flowing blonde locks seen on previous Versace faces, from Lady Gaga to Christina Aguilera.
— Versace (@Versace) December 4, 2014
She is starring in the luxury brand's campaigns for the fourth time since 1995, taking over the baton for this season from Lady Gaga.
The Versace deal comes hot on the heels of Madonna's topless appearance in the December edition of Interview magazine which has been greeted with near universal acclaim and interpreted as an act of empowerment for women in their 50s.