Craig, along with the cast of the film, arrived in the Italian capital on Wednesday, Italian daily La Stampa reported.
There he was photographed alongside fellow star, the Italian actress Monica Bellucci. The pair were welcomed by Rome’s mayor Ignazio Marino and Culture Minister Dario Francheschini at Rome City Hall.
Filming will begin on Thursday and the cast will remain in the city until mid-March. The film will be released on November 6th in Italy.
Filming locations include the city’s business district EUR, as well as Nomentana, Corso Vittorio, Lungotevere, via della Conciliazione, the Verano cemetery and Monti.
The first scene will be shot at the entrance to the Museum of Roman Civilization.
Meanwhile, residents in the city are already looking at ways to cash in on the film star's visit with property owners on via Nomentana reportedly charging up to €1,000 a day to those who want to watch a car chase scene live, the British daily, The Mirror reported.
Filming for the 24th James Bond film is taking place in various parts of the world including Tangier in Morocco, Mexico City, London and Sölden in Austria, where filming is still in progress.
The cast’s arrival in the city comes after reports that three British members of the film’s crew, aged 28, 52 and 63 were injured on the Austrian set for the film.
The accident happened during the filming of a stunt scene in Sölden when a car veered off the road and crashed into a camera platform.
The Austrian Press Agency reported that one British man was caught between the car and the platform and seriously injured, and two other crew members where thrown off the platform.
One also suffered serious injuries and the third man escaped with only minor injuries. Two of the men were airlifted to hospital and the third was treated by medics at the scene.
According to the Hollywood Reporter one of the injured men is second-unit director Terry Madden, who suffered multiple fractures.
It was the second accident to hit Spectre. Last week James Bond star Daniel Craig injured his knee while shooting a fight scene at Pinewood Studios in London.
Spectre is directed by Sam Mendes and opens in the UK on October 23rd and worldwide two weeks later.
It also stars double Oscar-winner Christoph Waltz as the villain, Lea Seydoux, Naomie Harris and Dave Bautista.