The eight-bedroom villa, located near Siena, was bought by the Renaissance master in 1549 and remained in the Buonarroti family until 1867 - more than 300 years after his death.
The home, surrounded by the vineyards of Chianti and views of Tuscany's rolling hills, could be yours for €7.5 million.
Whoever buys the villa, listed by the US-based property agency Handsome Properties International, will also get their hands on the original deed, which describes the Sistine Chapel painter as “a dear sculptor and Florentine citizen”.
“Since Michelangelo purchased the home in 1549, the home has only had three owners including the current owner, who possess the original deed to the property,” Annie Madren Young, an international consultant at Handsome Properties International, told The Local.
“The home is so special because it still showcases original details such as the barrelled brick ceiling and fireplaces.”
The property, believed to date back to the 11th century, also comes with eight bathrooms, an old mill and a lemon grove.
Even if you haven't a spare few million in the bank to buy the property, it's worth a look inside.
In pictures: A villa once owned by Michelangelo