The billionaire arrived in the Italian capital after spending a week in Lake Como, where he attended the wedding of Sofia and Daniel Ek, the CEO of Spotify.
The Townhall Q&A will be held at 4pm CET, the Facebook founder announced...on Facebook.
On Monday morning, he posted a photo of himself jogging by the Colosseum.
Zuckerberg's travels in Europe come after a report from the UK government lambasted Facebook, and others including Twitter and Google, for failing to do enough to fight extremism on their sites.
“Huge corporations like Google, Facebook and Twitter, with their billion dollar incomes, are consciously failing to tackle this threat and passing the buck by hiding behind their supranational legal status, despite knowing that their sites are being used by the instigators of terror,” Keith Vaz, a member of the UK parliament and chair of the committee that wrote the report, said in a statement.
“The companies' failure to tackle this threat has left some parts of the internet ungoverned, unregulated and lawless.”
During one of this last visits to Rome, Zuckerberg, whose net worth is USD 53.6 billion, failed to leave a tip after eating at a restaurant.
The incident occurred in 2012, during his honeymoon with new wife Priscilla Chan. The couple had eaten lunch at Nonna Betta, a popular kosher restaurant in the Jewish Ghetto, and didn't leave staff a tip after spending just €32.