In a press release, Ryanair said agreements had been signed "in principle" with unions FIT-CISL, ANPAC and ANPAV in Rome on Thursday.
Also on Thursday, Italian crews, alongside their Belgian, Dutch, Spanish and Portuguese counterparts announced a 24-hour stoppage on September 28th that unions said would be the biggest strike in the Irish carrier's history.
With confirmation of the agreement between Ryanair and the Italian crews – set to come into effect on October 1st for a period of three years – their participation in the forthcoming strike is unclear, with union leaders currently leading consultation on the matter.
According to unions, the agreement will allow for crews to work under contracts composed under Italian law rather than Irish legislation, addressing a key demand from staff. Provisions are also in place for salary increases and a pension scheme.
Ryanair and union leaders have yet to fine-tune some details for the collective agreement expected to be signed by the end of September.
"This agreement is a further sign of the significant progress Ryanair is making in reaching agreements with our people and their unions in different EU countries", Ryanair's chief of personnel Eddie Wilson said in a statement.
Ryanair has already reached an agreement with cabin crew in Ireland and the United Kingdom, but negotiations remain mired in difficulty in other countries.
On Wednesday, the company faced strike action from German pilot and cabin crew unions that resulted in the cancellation of 150 flights. Wilson said that "smaller unions" outside the negotiations process are threatening strikes that "will either not take place or be unsuccessful".