“Two skeletons of individuals caught in the fury of the eruption have been found,” officials at the Italian site near Naples said in a statement.
The researchers believe the figures are those of a young slave and a richer older man, around 40 and presumed to be his owner, based on the vestiges of clothing and their physical appearance.
The bodies of the two men, killed almost 2,000 years ago, are rported to be in an exceptionally well-preserved condition.
The ruined city of Pompeii was submerged in ash after the eruption of Mount Vesuvius in 79 AD. It is now Italy's second-most visited tourist attraction after Rome's Colosseum, receiving nearly four million visits last year.
The massive site that spreads over 44-hectares (110-acres) is what remains of one of one the richest cities in the Roman empire.
Layers of ash buried many buildings and objects in a nearly pristine state, including curled-up corpses of victims.
After the latest human remains were uncovered, the bones were analysed and then plaster was poured in, a technique invented by Giuseppe Fiorelli in 1867.
This creates a plaster cast which shows the shapes of the bodies of the two victims, in the supine position where they fell.
The two skeletons were found during ongoing excavations at Civita Giuliana, around 700 metres northwest of Pompeii, at a villa overlooking the Bay of Naples where previously a stable and the remains of three harnessed horses had been found.
The two bodies were found in a side room of the “cryptoporticus” a corridor below the villa where the could have gone to seek shelter.
While excavations continue at the Pompeii site, tourism has stopped due to coronavirus measures.