In a hugely symbolic move seen as a lesson in solidarity for Europe, Francis, who is himself the son of Italian migrants in Argentina, on Saturday took 12 Syrians from three families -- all Muslims -- home with him from Lesbos to the Vatican.
"All refugees are children of God," the 79-year-old pope said on the flight back to Rome referring to their religion, adding that though his gesture was "a drop in the ocean" he hoped "the ocean will never be the same again".
In an interview with Italian daily La Stampa, the families, who spent their first night in Rome at a Catholic charity, expressed their gratitude to the pontiff for his "gesture of hope".
"We saw friends and relatives die in the rubble, we fled Syria because we no longer had any hope," said Hasan, an engineer from Damascus, who arrived in Italy with his wife Nour and two-year-old son.
After fleeing to Turkey, Hasan and his family joined the migrant trail to Europe, piling into a rubber dinghy that set out from the Turkish coast for Greece. "But it was overloaded," said Hasan, recalling the pitch black of the sea at night and the waves rocking the vessel.
"In Lesbos, we understood that we were stuck in a place that we could not leave, (we were) in a trap, a prison", he said describing the pope as "our saviour" for whisking them off the island, where thousands of migrants risk being sent back to Turkey under a new EU-Turkey deportation deal.
Wafa, who was also on the papal flight from Lesbos with her husband Osama, eight-year-old daughter Masa and six-year-old son Omar, together with her husband, described the "constant bombardments" in recent months around their home.
"Since then (my son) has barely spoken... he is locked in an impenetrable silence," she said. "Even today, he wakes up every night crying and we cannot get him to play with his sister."
Wafa said she and her husband, who are from Damascus suburb of Zamalka, had opted to cut ties with the past.
"But we know we took the right decision," she said. After their stay on Lesbos, which seemed interminable, "Francis gave us a new life," she said.
Ramy, a 51-year-old teacher from the eastern Islamic State-occupied city of Deir Ezzor, fled Syria with his wife Suhila and three children -- sons Rashid, 18 and Abdelmajid, 16, and seven-year-old daughter Al Quds -- after their home was destroyed in the war.
"We discuss a lot and find it hard to imagine what life will be like in the future: we don't know whether we will start over in Europe or whether, one day, we will be able to return to a Syria free of war and violence," he told La Stampa.
"We are grateful to the pope, we will prove ourselves worthy of this opportunity and the gift he gave us," he told La Stampa, while adding he did not know whether he would remain in Europe for the long-term or "one day, return to a Syria that is free of war and violence."
The three families, who had initially set their sights on reaching Germany or another European country, are now expected to seek asylum in Italy.
Their arrival brings to around 20 the number of refugees living in the Vatican, which has under 1,000 inhabitants.
A similar intake across Europe would see six million people given asylum on the continent of 300 million.
Last year, the pope had appealed to every Catholic diocese in Europe to take in a refugee family -- an appeal that fell on deaf ears in most parts of the continent.
Migrant arrivals in Greece have drastically fallen since Turkey agreed to take back all irregular migrants landing on the Greek islands in return for billions in EU cash and other concessions.
Over 1.1 million people have crossed clandestinely from Turkey to Greece since the start of 2015, with hundreds drowning en route.