The bees attacked the man, stinging him several times as he left the garden of his home in Bagno di Romana, where he lived with his wife and two teenage children, Il Resto di Carlino reported.
Even though he had no history of insect allergies, the numerous stings provoked a fatal anaphylactic shock. The reaction was described as "rapid and severe".
His family immediately called emergency services, who rushed to the scene but were unable to save him.
The man, who worked in the offices of a local warehouse, was described by local relatives as "a gentle giant".
"He was always smiling and always ready to offer a hand to everyone whenever necessary," a relative told the newspaper.