Here are five key things to watch.
Interior minister Matteo Salvini tops the list for his anti-immigrant League party in all five Italian constituencies — despite saying he has no intention of returning to the European Parliament. His bids to form an alliance with right-wing populist and nationalist parties across the continent have struggled to gain traction.
Matteo Salvini (centre) with members of Finnish, German and Danish nationalist parties. Photo: Miguel Medina/AFP
With the League now Italy's most popular party, with over 30 percent of voter intentions according to opinion polls, it is counting on the European elections to assert its authority in Italy and Europe.
Five Star Women
Luigi Di Maio, head of the anti-establishment Five Star Movement (M5S), which governs in a coalition with the League, has nominated five women to lead his lists: an entrepreneur, a professor, two civil servants and a journalist.
Di Maio won the necessary support from the movement's members online, but there was grumbling over his decision to choose unknown figures who have had little experience within M5S to date.
— Luigi Di Maio (@luigidimaio) April 13, 2019
The movement can ill afford to do badly: it has been losing ground since coming to power in June and flopped in a series of local elections, including in the south, which was once its power base.
Billionaire Silvio Berlusconi is hoping for his umpteenth political comeback. The 82-year old has shrugged off legal woes to throw his hat into the ring once more for his centre-right Forza Italia (FI) party, which he founded 25 years ago.
Silvio Berlusconi on the campaign trail. Photo: Tiziana Fabi/AFP
Once renowned for his “bunga bunga” erotic dinner parties, Berlusconi is trying to reinvent himself as an experienced statesman who can save Italy from populism — while maintaining good ties with the League.
Mafia hunter, migrant saver
Back in 2014, a record 40 percent of Italians voted for the centre-left Democratic Party (PD) under Matteo Renzi. Now the party would be pleased to win just half that number of ballots.
The new leader, Nicola Zingaretti, has asked some of civil society's most symbolic figures to help the left recover. Among them are Franco Roberti, a renowned magistrate and former national anti-mafia prosecutor, and Pietro Bartolo, a famous doctor from the island of Lampedusa, the front line for migrant rescues in the Mediterranean.
Anti-mafia prosecutor Franco Roberti. Photo: Filippo Monteforte/AFP
Italian dictator Benito Mussolini's granddaughter, sitting MEP Alessandra Mussolini, 56, is running for Berlusconi's FI party, while her cousin's son Caio Giulio Cesare Mussolini, 50, is running for the small, far-right Brothers of Italy party.
They are on lists in different constituencies and both are being given good odds.